Developmental Neuroimmunology Lab
at

    Duke University


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In the Developmental Neuroimmunology Lab, we are interested in how the nervous, endocrine, and immune systems interact, particularly in the context of development and during sensitive periods such as adolescence.  We use rodent models to explore the mechanisms by which an organism's early perinatal environment (e.g., social, infectious, hormonal) influences brain and immune system development, and the subsequent implications for cognitive and affective abilities throughout the remainder of the lifespan. 



NeuN in DG of hippocampus                                                                                       Microglia (1ba1)

Students in this lab can expect to learn skills in small animal handling, injections, and surgical techniques; tissue dissection, immunohistochemistry, and in situ hybridization; confocal and stereology microscopy; cell culture techniques, including primary glial cell and neuronal cultures; flow cytometry; enzyme-linked immunosorbant assay (ELISA); quantitative real-time PCR; western blotting and immunoprecipitation; epigenetic analyses, and complex behavioral assessments, including learning and memory, anxiety and depressive-like behaviors, and addiction and reward.
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