Josh Granek

I am a systems biologist who is interested in the biology of interactions between organisms, particularly at the cellular and molecular scale. My research focuses on fungal biofilms using both wet lab and computational methods. I have developed Saccharomyces cerevisiae colony biofilms as a model for understanding how microbes interact to generate multicellular behavior.

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Google Scholar Profile

1. Joshua A Granek, Debra Murray, Ömür Kayıkçı, Paul M. Magwene. Natural Variation across a Cell-Signaling Pathway Alters Colony Biofilms in Yeast. Genetics, 193(2):587-600, Feb 2013. pubmed | doi | PMC
2. Joshua A Granek, Ömür Kayıkçı, Paul M. Magwene. Pleiotropic Signaling Pathways in Yeast Development. Curr Opin Microbiol, 14(6):676–81, Dec 2011. pubmed | doi | PMC
   • Selected for journal cover image
3. Paul M. Magwene, Ömür Kayıkçı, Joshua A Granek, Jennifer Reininga, and Debra Murray. Outcrossing, Mitotic Recombination, and Life-History Tradeoffs Shape Genome Evolution in Saccharomyces cerevisiae. PNAS, 108(5):1987–92, Feb 2011. pubmed | doi | pdf
4. Joshua A Granek and Paul M Magwene. Environmental and Genetic Determinants of Colony Morphology in Yeast. PLoS Genet, 6(1):e1000823, Jan 2010. pubmed | doi | pdf
   • Faculty of 1000 FFa rating of 6
5. Xiao Liu, Cheol-Koo Lee, Joshua A Granek, Neil D Clarke, and Jason D Lieb. Whole–Genome Comparison of Leu3 Binding in vitro and in vivo Reveals the Importance of Nucleosome Occupancy in Target Site Selection. Genome Res, 16(12):1517–28, Dec 2006. pubmed | doi | pdf
6. Joshua A Granek and Neil D Clarke. Explicit Equilibrium Modeling of Transcription-Factor Binding and Gene Regulation. Genome Biol, 6(10):R87, Jan 2005. pubmed | doi | pdf
7. Kristina L Carroll, Dennis A Pradhan, Josh A Granek, Neil D Clarke, and Jeffry L Corden. Identification of cis Elements Directing Termination of Yeast Nonpolyadenylated snoRNA Transcripts. Mol Cell Biol, 24(14):6241–52, Jul 2004. pubmed | doi | pdf
8. Neil D Clarke and Joshua A Granek. Rank Order Metrics for Quantifying the Association of Sequence Features with Gene Regulation. Bioinformatics, 19(2):212–8, Jan 2003. pubmed | doi | pdf
9. Tatiana G Senkevich, Christine L White, Andrea Weisberg, Joshua A Granek, Elizabeth J Wolffe, Eugene V Koonin, and Bernard Moss. Expression of the Vaccinia Virus A2.5L Redox Protein is Required for Virion Morphogenesis. Virology, 300(2):296–303, Sep 2002. pubmed | doi | pdf
10. D M Noll, A Gogos, J A Granek, and N D Clarke. The C-Terminal Domain of the Adenine-DNA Glycosylase MutY Confers Specificity For 8-Oxoguanine—Adenine Mispairs and May Have Evolved From MutT, An 8-Oxo-dGTPase. Biochemistry, 38(20):6374–9, May 1999. pubmed | doi | pdf

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