Welcome to my old home page.
As of December 2011, I am a Senior Lecturer (Assistant Professor)
in the Department of Human Biology at the University of Haifa:
I used to work in the
at the Duke University
in Durham, North Carolina.
My interests are focused on the field of
signal transduction. In particular, I aim to decipher how structure encodes interaction
specificity at the protein-family level.
The model system I study is the interactions of G-proteins with the proteins that turn them "off",
the Regulators of G-protein Signaling (RGSs). These families play central roles in communication
within and between cells and are involved in numerous diseases such as cancer,
hypertension, and schizophrenia; they are therefore important targets for basic and applied research.
Before coming to Duke I was a post-doctoral fellow in
Barry Honig's Lab
Department of Biochemistry and Molecular Biophysics
at Columbia University in New York.
In the Honig lab I focused on computational approaches to understand how
structure determines function and specificity in particular proteins,
worked on quantifying structural differences and identifying sequence similar,
structure dissimilar proteins in the PDB,
and studied the interactions of G-proteins with membranes.
I participated in the Critical Assessment of Techniques for Protein Structure
in 2004 as part of the Honig group effort in that experiment, where our
group came in 5th out of more than 200 participating groups.
I also assisted with the prediction of selected signal transduction
targets in CASP7.
I completed my PhD studies (Summa Cum Laude) in the
Department of Biological Chemistry
(Institute of Life Sciences)
at The Hebrew University.
My doctoral advisor was
(a few more details about him (in Hebrew) are in the
EMET Prize website
Israeli Prize website).
In the fall of 2000 I spent 3 months in Arieh Warshel's group, using molecular simulation to study enzymatic catalysis in the G-protein Ras.
After submitting my thesis and before coming to New York I worked in
Shy Arkin's lab,
searching for membrane-targeting motifs in signaling proteins and analyzing novel SARS
Even more distant past:
I received my B.Sc. in Chemistry (Summa Cum Laude) in the 'Amirim' honor program at The Hebrew University. Beyond that, it's all a blur...
This website is out of date. See link to new website above.
In memory of
Typos for Mickey Kosloff (for Google):
Miki, Mikey, Micky, Micki, Nicki, Koslof,
Kozlov, Koslov, Kozloff, Kozalov.
Hebrew: מיקי קוזלוב