Genes Silenced by Promoter Methylation in Lung Cancer

• cell cycle control p16, others

• tumor cell invasion cadherins

• cell growth control APC

• DNA repair MGMT

• apoptosis DAPK

~600 genes with hypermethylated CpG islands in cancer

Re-expression of these genes are the true targets of “DNA methylation” therapeutic strategies

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APC Clin Cancer Res. 2001 Jul;7(7):1998-2004.