Decitabine

• Induces re-expression of p16 and other genes in tumor cells in vitro (~1 uM)

• Reduces tumorigenicity in vivo of tumor cells exposed in vitro

• Induces p16 in human tumor xenograft in rats

• Inactive in solid tumors in phase I/II trials in 1980’s as short infusion

Cancer Res 1998 Jan 1;58(1):95-101

EORTC 5-aza-2’-deoxycytidine. Preclinical and clinical trials. PCH Publications, Haarlem, The Netherlands, 1990

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