Phase I Study of Decitabine

• 19 pt's: 12 melanoma, 4 breast, kidney, colon, bladder

• DAC 20-40 mg/m2/d CIV x 3d q 28d

• MTD = 30 mg/m2/d CIV x 3 d q 28d; DLT = neutropenia

• No objective responses

• tumor biopsies before and on day 7; methylation of 16 genes: no change in degree of methylation

Weber JS et al, 2001 PASCO

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