MG-98
Second generation phosphorothioate antisense oligonucleotide for DNMT1
In vitro inhibition of DNMT1 transcription, IC50 50-70 nM
Phase I trial: DLT observed (hepatic)
- Css = 90-598 nM at tolerable doses
Phase II studies in H&N, renal cell
Siu LL, et al., 2000 PASCO